Renoprotective Effects of Olive Leaf Extract on Kidney Function and Histopathology in Ovalbumin-Induced Asthmatic BALB/c Mice
Abstract
Purpose of the study: This study aimed to evaluate the potential of olive leaf extract–based herbal therapy on renal structure and function in BALB/c mice with experimentally induced asthma.
Methodology: A true experimental laboratory design was conducted using 24 male BALB/c mice divided into four groups: normal control, asthma control, low-dose (100 mg/kgBW), and high-dose (200 mg/kgBW) olive leaf extract treatment. Asthma was induced via ovalbumin sensitization and challenge. Serum creatinine, blood urea nitrogen (BUN), and kidney histopathology were assessed.
Main Findings: Asthma induction significantly elevated creatinine (0.61 ± 0.07 mg/dL) and BUN (29.7 ± 3.4 mg/dL) levels and caused moderate renal histopathological damage (median 2 [2–3]). Treatment with olive leaf extract reduced creatinine to 0.48 ± 0.06 mg/dL and 0.45 ± 0.05 mg/dL, BUN to 22.6 ± 2.8 mg/dL and 20.9 ± 2.5 mg/dL, and histopathological scores to median 1 (1–2) and 1 (0–1) for low- and high-dose groups, respectively.
Novelty/Originality of this study: This study provides the first integrative evaluation of renal protection by olive leaf extract in asthma-induced systemic inflammation, highlighting both functional and structural benefits at therapeutic doses.
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